许琳 副教授

来源: 发布时间:2025-04-16 20:00:27

  许琳,1992年生,安徽合肥人,本科毕业于安徽医科大学,硕士毕业于山东大学,博士和博士后均在伟德betvlctor体育官网。现为bv1946伟德国际始于英国副教授,硕士生导师。

一、研究方向:肝脏毒理学,表观遗传(非编码小RNA

二、主要科研项目

  1. 国家自然科学基金委青年项目,tRFs-5Glu-TTC家族引发内质网应激在二甲基甲酰胺致肝损伤中的作用及机制研究,2023/1-2025/1230万,在研,主持。

  2. 中国博士后面上项目,tRNA来源的小RNA在二甲基甲酰胺致肝毒性终的作用及机制研究,2023/1-2024/128万,已结题,主持。

三、近五年代表性科研成果(一作/共同一作)

  1. Xu L, Ma W, Huo X, Luo J, Li R, Zhu X, Kong X, Zhao K, Jin Y, Zhang M et al: New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM(2.5)-induced lung cancer. J Adv Res 2024. (IF=11.4)

  2. Ma W*, Xu L*, Wang Y, Chen S, Li D, Huo X, Li R, Zhu X, Chen N, Jin Y et al: piR-27222 mediates PM(2.5)-induced lung cancer by resisting cell PANoptosis through the WTAP/m(6)A axis. Environment international 2024, 190:108928. (IF=10.3)

  3. Xu L*, Li Y*, Ma W, Sun X, Fan R, Jin Y, Chen N, Zhu X, Guo H, Zhao K et al: Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk. Journal of hazardous materials, 2023, 458:132060. (IF=12.2).

  4. Fan R*, Xu L*, Cui B, Li D, Sun X, Qi Y, Rao J, Wang K, Wang C, Zhao K et al: Genomic Characterization Revealed PM(2.5)-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B. Environmental science & technology 2023, 57(17):6854-6864. (IF=10.9).

  5. Xu L*, Ma W*, Jin Y, Sun X, Chen N, Zhu X, Luo J, Li C, Zhao K, Zheng Y et al: N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro. The Science of the total environment 2022, 839:156218. (IF=9.8).

  6. Ma W*, Xu L*, Sun X, Qi Y, Chen S, Li D, Jin Y, Chen N, Zhu X, Luo J et al: Using a human bronchial epithelial cell-based malignant transformation model to explore the function of hsa-miR-200 family in the progress of PM(2.5)-induced lung cancer development. Environmental pollution (Barking, Essex : 1987) 2023, 319:120981. (IF=8.9).

  7. Xu L*, Sun X*, Wang Y, Zhou T, Jia J, et al: Functional polymorphisms in Benzo(a)Pyrene-induced toxicity pathways associated with the risk on laryngeal squamous cell carcinoma. Food and Chemical Toxicology, 2023. (IF=3.9).

  8. Xu L, Chen W, Chen J, Jin Y, Ma W, Qi G, Sun X, Luo J, Li C, Zhao K et al: PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A. Biochemical pharmacology 2021:114897. (IF=5.3).

  9. Xu L*, Zhao Q*, Luo J, Ma W, Jin Y, Li C, Hou Y, Feng M, Wang Y, Chen J et al: Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity. Ecotoxicology and environmental safety 2020, 205:111166. (IF=6.2).

四、主要学术兼职

中国毒理学会类器官与器官芯片毒理学专业委员会委员

五、联系方式

xulin992@163.com




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